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QX-222 chloride

CAS No. 5369-00-6

QX-222 chloride( QX 222 | Lidocaine N-Methyl Hydrochloride )

Catalog No. M27693 CAS No. 5369-00-6

QX222 is a sodium channel blocker.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    QX-222 chloride
  • Note
    Research use only, not for human use.
  • Brief Description
    QX222 is a sodium channel blocker.
  • Description
    QX222 is a sodium channel blocker.(In Vitro):Compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001), μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block twelve minutes after external application of 500 μM QX222 chloride.(In Vivo):Intravenous infusion administration of 10 mg/kg QX-222 chloride for 7 days reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats.
  • In Vitro
    Twelve minutes after external application of 500 μM QX222 chloride, μ1 IP-Loop to Heart Sequence (μ1-Y401C) results in a significant block compared with μ1-WT (WT, 14.2±1.6% block, n = 8; Y401C, 45.2±3.6% block, n = 9; P < 0.001).
  • In Vivo
    QX-222 (10 mg/kg; intravenous infusion 7 days) chloride reverses spinal nerve ligation (SNL)-induced thermal hypersensitivity and induced antinociception in sham-operated rats.
  • Synonyms
    QX 222 | Lidocaine N-Methyl Hydrochloride
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    c-Src
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    5369-00-6
  • Formula Weight
    220.316
  • Molecular Formula
    C13H20N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (486.82 mM)
  • SMILES
    Cc1cccc(C)c1\N=C(/[O-])C[N+](C)(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.O'Malley DP, et al. Discovery of Pyridazinone and Pyrazolo[1,5-a]pyridine Inhibitors of C-Terminal Src Kinase. ACS Med Chem Lett. 2019 Sep 25;10(10):1486-1491.
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